diff --git a/plugins/woocommerce-admin/client/wp-admin-scripts/command-palette-analytics/index.js b/plugins/woocommerce-admin/client/wp-admin-scripts/command-palette-analytics/index.js
index f04a592f368..07cc96e9510 100644
--- a/plugins/woocommerce-admin/client/wp-admin-scripts/command-palette-analytics/index.js
+++ b/plugins/woocommerce-admin/client/wp-admin-scripts/command-palette-analytics/index.js
@@ -3,6 +3,7 @@
  */
 import { __, sprintf } from '@wordpress/i18n';
 import { chartBar } from '@wordpress/icons';
+import { useEffect } from '@wordpress/element';
 import { registerPlugin } from '@wordpress/plugins';
 import { addQueryArgs } from '@wordpress/url';
 
@@ -34,21 +35,24 @@ const registerWooCommerceAnalyticsCommand = ( { label, path, origin } ) => {
 const WooCommerceAnalyticsCommands = () => {
 	const { editedPostType } = useEditedPostType();
 	const origin = editedPostType ? editedPostType + '-editor' : null;
-	if (
-		window.hasOwnProperty( 'wcCommandPaletteAnalytics' ) &&
-		window.wcCommandPaletteAnalytics.hasOwnProperty( 'reports' ) &&
-		Array.isArray( window.wcCommandPaletteAnalytics.reports )
-	) {
-		const analyticsReports = window.wcCommandPaletteAnalytics.reports;
 
-		analyticsReports.forEach( ( analyticsReport ) => {
-			registerWooCommerceAnalyticsCommand( {
-				label: analyticsReport.title,
-				path: analyticsReport.path,
-				origin,
+	useEffect( () => {
+		if (
+			window.hasOwnProperty( 'wcCommandPaletteAnalytics' ) &&
+			window.wcCommandPaletteAnalytics.hasOwnProperty( 'reports' ) &&
+			Array.isArray( window.wcCommandPaletteAnalytics.reports )
+		) {
+			const analyticsReports = window.wcCommandPaletteAnalytics.reports;
+
+			analyticsReports.forEach( ( analyticsReport ) => {
+				registerWooCommerceAnalyticsCommand( {
+					label: analyticsReport.title,
+					path: analyticsReport.path,
+					origin,
+				} );
 			} );
-		} );
-	}
+		}
+	}, [ origin ] );
 
 	return null;
 };
diff --git a/plugins/woocommerce-admin/client/wp-admin-scripts/command-palette/index.js b/plugins/woocommerce-admin/client/wp-admin-scripts/command-palette/index.js
index 31cfcbaf68c..992404c42dc 100644
--- a/plugins/woocommerce-admin/client/wp-admin-scripts/command-palette/index.js
+++ b/plugins/woocommerce-admin/client/wp-admin-scripts/command-palette/index.js
@@ -136,71 +136,74 @@ const WooCommerceCommands = () => {
 		wasCommandPaletteOpen.current = isCommandPaletteOpen;
 	}, [ isCommandPaletteOpen, origin ] );
 
-	registerCommandWithTracking( {
-		name: 'woocommerce/add-new-product',
-		label: __( 'Add new product', 'woocommerce' ),
-		icon: plus,
-		callback: () => {
-			document.location = addQueryArgs( 'post-new.php', {
-				post_type: 'product',
-			} );
-		},
-		origin,
-	} );
-	registerCommandWithTracking( {
-		name: 'woocommerce/add-new-order',
-		label: __( 'Add new order', 'woocommerce' ),
-		icon: plus,
-		callback: () => {
-			document.location = addQueryArgs( 'admin.php', {
-				page: 'wc-orders',
-				action: 'new',
-			} );
-		},
-		origin,
-	} );
-	registerCommandWithTracking( {
-		name: 'woocommerce/view-products',
-		label: __( 'Products', 'woocommerce' ),
-		icon: box,
-		callback: () => {
-			document.location = addQueryArgs( 'edit.php', {
-				post_type: 'product',
-			} );
-		},
-		origin,
-	} );
-	registerCommandWithTracking( {
-		name: 'woocommerce/view-orders',
-		label: __( 'Orders', 'woocommerce' ),
-		icon: box,
-		callback: () => {
-			document.location = addQueryArgs( 'admin.php', {
-				page: 'wc-orders',
-			} );
-		},
-		origin,
-	} );
-	dispatch( commandsStore ).registerCommandLoader( {
-		name: 'woocommerce/product',
-		hook: useProductCommandLoader,
-	} );
-
-	if (
-		window.hasOwnProperty( 'wcCommandPaletteSettings' ) &&
-		window.wcCommandPaletteSettings.hasOwnProperty( 'settingsTabs' ) &&
-		Array.isArray( window.wcCommandPaletteSettings.settingsTabs )
-	) {
-		const settingsCommands = window.wcCommandPaletteSettings.settingsTabs;
-
-		settingsCommands.forEach( ( settingsCommand ) => {
-			registerWooCommerceSettingsCommand( {
-				label: settingsCommand.label,
-				tab: settingsCommand.key,
-				origin,
-			} );
+	useEffect( () => {
+		registerCommandWithTracking( {
+			name: 'woocommerce/add-new-product',
+			label: __( 'Add new product', 'woocommerce' ),
+			icon: plus,
+			callback: () => {
+				document.location = addQueryArgs( 'post-new.php', {
+					post_type: 'product',
+				} );
+			},
+			origin,
 		} );
-	}
+		registerCommandWithTracking( {
+			name: 'woocommerce/add-new-order',
+			label: __( 'Add new order', 'woocommerce' ),
+			icon: plus,
+			callback: () => {
+				document.location = addQueryArgs( 'admin.php', {
+					page: 'wc-orders',
+					action: 'new',
+				} );
+			},
+			origin,
+		} );
+		registerCommandWithTracking( {
+			name: 'woocommerce/view-products',
+			label: __( 'Products', 'woocommerce' ),
+			icon: box,
+			callback: () => {
+				document.location = addQueryArgs( 'edit.php', {
+					post_type: 'product',
+				} );
+			},
+			origin,
+		} );
+		registerCommandWithTracking( {
+			name: 'woocommerce/view-orders',
+			label: __( 'Orders', 'woocommerce' ),
+			icon: box,
+			callback: () => {
+				document.location = addQueryArgs( 'admin.php', {
+					page: 'wc-orders',
+				} );
+			},
+			origin,
+		} );
+		dispatch( commandsStore ).registerCommandLoader( {
+			name: 'woocommerce/product',
+			hook: useProductCommandLoader,
+		} );
+
+		if (
+			window.hasOwnProperty( 'wcCommandPaletteSettings' ) &&
+			window.wcCommandPaletteSettings.hasOwnProperty( 'settingsTabs' ) &&
+			Array.isArray( window.wcCommandPaletteSettings.settingsTabs )
+		) {
+			const settingsCommands =
+				window.wcCommandPaletteSettings.settingsTabs;
+
+			settingsCommands.forEach( ( settingsCommand ) => {
+				registerWooCommerceSettingsCommand( {
+					label: settingsCommand.label,
+					tab: settingsCommand.key,
+					origin,
+				} );
+			} );
+		}
+	}, [ origin ] );
 
 	return null;
 };
diff --git a/plugins/woocommerce/changelog/43221-fix-command-palette-unnecessary-scripts b/plugins/woocommerce/changelog/43221-fix-command-palette-unnecessary-scripts
new file mode 100644
index 00000000000..63644a9ca19
--- /dev/null
+++ b/plugins/woocommerce/changelog/43221-fix-command-palette-unnecessary-scripts
@@ -0,0 +1,4 @@
+Significance: patch
+Type: fix
+
+Fix `Store "core/interface" is already registered.` error in the block editor.
\ No newline at end of file
diff --git a/plugins/woocommerce/includes/admin/class-wc-admin-assets.php b/plugins/woocommerce/includes/admin/class-wc-admin-assets.php
index bf482c4e3f6..9b5b4e425b7 100644
--- a/plugins/woocommerce/includes/admin/class-wc-admin-assets.php
+++ b/plugins/woocommerce/includes/admin/class-wc-admin-assets.php
@@ -556,6 +556,25 @@ if ( ! class_exists( 'WC_Admin_Assets', false ) ) :
 			}
 		}
 
+		/**
+		 * Enqueue a script in the block editor.
+		 * Similar to `WCAdminAssets::register_script()` but without enqueuing unnecessary dependencies.
+		 *
+		 * @return void
+		 */
+		private function enqueue_block_editor_script( $script_path_name, $script_name ) {
+			$script_assets_filename = WCAdminAssets::get_script_asset_filename( $script_path_name, $script_name );
+			$script_assets          = require WC_ADMIN_ABSPATH . WC_ADMIN_DIST_JS_FOLDER .  $script_path_name . '/' . $script_assets_filename;
+
+			wp_enqueue_script(
+				'wc-admin-' . $script_name,
+				WCAdminAssets::get_url( $script_path_name . '/' . $script_name, 'js' ),
+				$script_assets['dependencies'],
+				WCAdminAssets::get_file_version( 'js' ),
+				true
+			);
+		}
+
 		/**
 		 * Enqueue block editor assets.
 		 *
@@ -578,7 +597,7 @@ if ( ! class_exists( 'WC_Admin_Assets', false ) ) :
 					}
 				}
 
-				WCAdminAssets::register_script( 'wp-admin-scripts', 'command-palette' );
+				self::enqueue_block_editor_script( 'wp-admin-scripts', 'command-palette' );
 				wp_localize_script(
 					'wc-admin-command-palette',
 					'wcCommandPaletteSettings',
@@ -611,7 +630,7 @@ if ( ! class_exists( 'WC_Admin_Assets', false ) ) :
 					}, $analytics_reports );
 					$formatted_analytics_reports = array_filter( $formatted_analytics_reports, 'is_array' );
 
-					WCAdminAssets::register_script( 'wp-admin-scripts', 'command-palette-analytics' );
+					self::enqueue_block_editor_script( 'wp-admin-scripts', 'command-palette-analytics' );
 					wp_localize_script(
 						'wc-admin-command-palette-analytics',
 						'wcCommandPaletteAnalytics',