diff --git a/plugins/woocommerce/changelog/fix-45699 b/plugins/woocommerce/changelog/fix-45699
new file mode 100644
index 00000000000..bf65ee114e1
--- /dev/null
+++ b/plugins/woocommerce/changelog/fix-45699
@@ -0,0 +1,4 @@
+Significance: minor
+Type: performance
+
+Add index on SKU filed in wc_product_meta_lookup table
diff --git a/plugins/woocommerce/includes/class-wc-install.php b/plugins/woocommerce/includes/class-wc-install.php
index 84fb2f015b4..90d3aff76b0 100644
--- a/plugins/woocommerce/includes/class-wc-install.php
+++ b/plugins/woocommerce/includes/class-wc-install.php
@@ -1599,7 +1599,8 @@ CREATE TABLE {$wpdb->prefix}wc_product_meta_lookup (
   KEY `stock_status` (`stock_status`),
   KEY `stock_quantity` (`stock_quantity`),
   KEY `onsale` (`onsale`),
-  KEY min_max_price (`min_price`, `max_price`)
+  KEY min_max_price (`min_price`, `max_price`),
+  KEY sku (sku(50))
 ) $collate;
 CREATE TABLE {$wpdb->prefix}wc_tax_rate_classes (
   tax_rate_class_id bigint(20) unsigned NOT NULL auto_increment,