diff --git a/plugins/woocommerce-admin/client/marketplace/components/product-card/product-card.scss b/plugins/woocommerce-admin/client/marketplace/components/product-card/product-card.scss
index 524c47155d3..9f3d404d053 100644
--- a/plugins/woocommerce-admin/client/marketplace/components/product-card/product-card.scss
+++ b/plugins/woocommerce-admin/client/marketplace/components/product-card/product-card.scss
@@ -4,6 +4,7 @@
 	&__product-card {
 		padding: $large-gap;
 		border-radius: $grid-unit-05 !important;
+		margin-bottom: 0;
 
 		/* When product card is loading, contents will be empty and we render skeleton loader wireframes: */
 		&.is-loading {
@@ -243,7 +244,7 @@
 		}
 
 		&.woocommerce-marketplace__product-card--theme {
-			padding: 0 0 $medium-gap;
+			padding: 0 0 $large-gap;
 			overflow: hidden;
 
 			.woocommerce-marketplace__product-card__content {
@@ -265,10 +266,10 @@
 				right: 0;
 			}
 			.woocommerce-marketplace__product-card__header {
-				padding-left: $medium-gap;
+				padding: 0 $large-gap;
 			}
 			.woocommerce-marketplace__product-card__footer {
-				padding: 0 $medium-gap;
+				padding: 0 $large-gap;
 			}
 			.woocommerce-marketplace__product-card__price {
 				margin-right: $medium-gap;
@@ -313,7 +314,7 @@
 					display: flex;
 					flex-direction: column;
 					gap: $small-gap;
-					padding: 16px 24px;
+					padding: $large-gap;
 					height: 100%;
 				}
 
diff --git a/plugins/woocommerce/changelog/51288-update-wccom-21570-in-app-product-cards-padding b/plugins/woocommerce/changelog/51288-update-wccom-21570-in-app-product-cards-padding
new file mode 100644
index 00000000000..1f91bb228e1
--- /dev/null
+++ b/plugins/woocommerce/changelog/51288-update-wccom-21570-in-app-product-cards-padding
@@ -0,0 +1,4 @@
+Significance: patch
+Type: tweak
+
+Update product card content padding to 24px and add 0 margin bottom to product cards
\ No newline at end of file