diff --git a/packages/js/product-editor/changelog/add-keyboard-shortcuts b/packages/js/product-editor/changelog/add-keyboard-shortcuts
new file mode 100644
index 00000000000..e09c109e440
--- /dev/null
+++ b/packages/js/product-editor/changelog/add-keyboard-shortcuts
@@ -0,0 +1,4 @@
+Significance: minor
+Type: add
+
+Allow saving a product as a draft when hitting ctrl/cmd + S
diff --git a/packages/js/product-editor/src/components/block-editor/block-editor.tsx b/packages/js/product-editor/src/components/block-editor/block-editor.tsx
index ba72d28406f..8b1ae44266e 100644
--- a/packages/js/product-editor/src/components/block-editor/block-editor.tsx
+++ b/packages/js/product-editor/src/components/block-editor/block-editor.tsx
@@ -14,6 +14,7 @@ import { uploadMedia } from '@wordpress/media-utils';
 import { PluginArea } from '@wordpress/plugins';
 import { __ } from '@wordpress/i18n';
 import { useLayoutTemplate } from '@woocommerce/block-templates';
+import { store as keyboardShortcutsStore } from '@wordpress/keyboard-shortcuts';
 import { Product } from '@woocommerce/data';
 import {
 	// eslint-disable-next-line @typescript-eslint/ban-ts-comment
@@ -94,6 +95,23 @@ export function BlockEditor( {
 		return () => window.removeEventListener( 'scroll', wpPinMenuEvent );
 	}, [] );
 
+	// @ts-expect-error Type definitions are missing
+	const { registerShortcut } = useDispatch( keyboardShortcutsStore );
+
+	useEffect( () => {
+		if ( registerShortcut ) {
+			registerShortcut( {
+				name: 'core/editor/save',
+				category: 'global',
+				description: __( 'Save your changes.', 'woocommerce' ),
+				keyCombination: {
+					modifier: 'primary',
+					character: 's',
+				},
+			} );
+		}
+	}, [ registerShortcut ] );
+
 	const [ settingsGlobal, setSettingsGlobal ] = useState<
 		Partial< ProductEditorSettings > | undefined
 	>( undefined );
diff --git a/packages/js/product-editor/src/components/header/hooks/use-publish/use-publish.tsx b/packages/js/product-editor/src/components/header/hooks/use-publish/use-publish.tsx
index a2b0a73f41f..79ad697da6b 100644
--- a/packages/js/product-editor/src/components/header/hooks/use-publish/use-publish.tsx
+++ b/packages/js/product-editor/src/components/header/hooks/use-publish/use-publish.tsx
@@ -6,6 +6,7 @@ import { Button } from '@wordpress/components';
 import { useEntityProp } from '@wordpress/core-data';
 import { __ } from '@wordpress/i18n';
 import type { Product } from '@woocommerce/data';
+import { useShortcut } from '@wordpress/keyboard-shortcuts';
 
 /**
  * Internal dependencies
@@ -41,6 +42,9 @@ export function usePublish< T = Product >( {
 	const isDisabled =
 		prevStatus !== 'draft' && ( disabled || isBusy || ! isDirty );
 
+	const handlePublish = () =>
+		publish().then( onPublishSuccess ).catch( onPublishError );
+
 	function handleClick( event: MouseEvent< HTMLButtonElement > ) {
 		if ( isDisabled ) {
 			event.preventDefault?.();
@@ -51,7 +55,7 @@ export function usePublish< T = Product >( {
 			onClick( event );
 		}
 
-		publish().then( onPublishSuccess ).catch( onPublishError );
+		handlePublish();
 	}
 
 	function getButtonText() {
@@ -69,6 +73,16 @@ export function usePublish< T = Product >( {
 		return __( 'Publish', 'woocommerce' );
 	}
 
+	useShortcut( 'core/editor/save', ( event ) => {
+		event.preventDefault();
+		if (
+			! isDisabled &&
+			( prevStatus === 'publish' || prevStatus === 'future' )
+		) {
+			handlePublish();
+		}
+	} );
+
 	return {
 		children: getButtonText(),
 		...props,
diff --git a/packages/js/product-editor/src/components/header/hooks/use-save-draft/use-save-draft.tsx b/packages/js/product-editor/src/components/header/hooks/use-save-draft/use-save-draft.tsx
index 83562841292..e5c3984b5c1 100644
--- a/packages/js/product-editor/src/components/header/hooks/use-save-draft/use-save-draft.tsx
+++ b/packages/js/product-editor/src/components/header/hooks/use-save-draft/use-save-draft.tsx
@@ -9,6 +9,7 @@ import { __ } from '@wordpress/i18n';
 import { check } from '@wordpress/icons';
 import { createElement, Fragment } from '@wordpress/element';
 import { MouseEvent, ReactNode } from 'react';
+import { useShortcut } from '@wordpress/keyboard-shortcuts';
 
 /**
  * Internal dependencies
@@ -69,22 +70,13 @@ export function useSaveDraft( {
 	// @ts-expect-error There are no types for this.
 	const { editEntityRecord, saveEditedEntityRecord } = useDispatch( 'core' );
 
-	async function handleClick( event: MouseEvent< HTMLButtonElement > ) {
-		if ( ariaDisabled ) {
-			return event.preventDefault();
-		}
-
-		if ( onClick ) {
-			onClick( event );
-		}
-
+	async function saveDraft() {
 		try {
 			await validate( { status: 'draft' } );
 
 			await editEntityRecord( 'postType', productType, productId, {
 				status: 'draft',
 			} );
-			// @ts-expect-error There are no types for this.
 			const publishedProduct = await saveEditedEntityRecord< Product >(
 				'postType',
 				productType,
@@ -104,6 +96,17 @@ export function useSaveDraft( {
 		}
 	}
 
+	async function handleClick( event: MouseEvent< HTMLButtonElement > ) {
+		if ( ariaDisabled ) {
+			return event.preventDefault();
+		}
+
+		if ( onClick ) {
+			onClick( event );
+		}
+		await saveDraft();
+	}
+
 	let children: ReactNode;
 	if ( productStatus === 'publish' ) {
 		children = __( 'Switch to draft', 'woocommerce' );
@@ -118,6 +121,16 @@ export function useSaveDraft( {
 		);
 	}
 
+	useShortcut( 'core/editor/save', ( event ) => {
+		event.preventDefault();
+		if (
+			! ariaDisabled &&
+			( productStatus === 'draft' || productStatus === 'auto-draft' )
+		) {
+			saveDraft();
+		}
+	} );
+
 	return {
 		children,
 		...props,
diff --git a/packages/js/product-editor/typings/index.d.ts b/packages/js/product-editor/typings/index.d.ts
index 67de76ccd18..24fa580c455 100644
--- a/packages/js/product-editor/typings/index.d.ts
+++ b/packages/js/product-editor/typings/index.d.ts
@@ -25,3 +25,7 @@ declare module '@wordpress/core-data' {
 		id: number | string
 	): { record: T, editedRecord: T };
 }
+declare module '@wordpress/keyboard-shortcuts' {
+	function useShortcut(name: string, callback: (event: KeyboardEvent) => void): void;
+	const store;
+}