diff --git a/plugins/woocommerce/changelog/51316-fix-51216-filter-by-stock-block-fails-with-ansi_quotes-enabled-database b/plugins/woocommerce/changelog/51316-fix-51216-filter-by-stock-block-fails-with-ansi_quotes-enabled-database
new file mode 100644
index 00000000000..37eb924dbb5
--- /dev/null
+++ b/plugins/woocommerce/changelog/51316-fix-51216-filter-by-stock-block-fails-with-ansi_quotes-enabled-database
@@ -0,0 +1,4 @@
+Significance: minor
+Type: fix
+
+Fix: Multiple issues related to MySQL having `ANSI_QUOTES` enabled in Product Filters
\ No newline at end of file
diff --git a/plugins/woocommerce/src/Blocks/QueryFilters.php b/plugins/woocommerce/src/Blocks/QueryFilters.php
index 274566be8b0..d3e783ba752 100644
--- a/plugins/woocommerce/src/Blocks/QueryFilters.php
+++ b/plugins/woocommerce/src/Blocks/QueryFilters.php
@@ -209,7 +209,7 @@ final class QueryFilters {
 		}
 
 		$args['join']   = $this->append_product_sorting_table_join( $args['join'] );
-		$args['where'] .= ' AND wc_product_meta_lookup.stock_status IN ("' . implode( '","', array_map( 'esc_sql', explode( ',', $wp_query->get( 'filter_stock_status' ) ) ) ) . '")';
+		$args['where'] .= ' AND wc_product_meta_lookup.stock_status IN (\'' . implode( '\',\'', array_map( 'esc_sql', explode( ',', $wp_query->get( 'filter_stock_status' ) ) ) ) . '\')';
 
 		return $args;
 	}
diff --git a/plugins/woocommerce/src/StoreApi/Utilities/ProductQuery.php b/plugins/woocommerce/src/StoreApi/Utilities/ProductQuery.php
index 3fce3214ab0..ddcbc15fea6 100644
--- a/plugins/woocommerce/src/StoreApi/Utilities/ProductQuery.php
+++ b/plugins/woocommerce/src/StoreApi/Utilities/ProductQuery.php
@@ -359,7 +359,7 @@ class ProductQuery {
 				$skus[] = $wp_query->get( 'sku' );
 			}
 			$args['join']   = $this->append_product_sorting_table_join( $args['join'] );
-			$args['where'] .= ' AND wc_product_meta_lookup.sku IN ("' . implode( '","', array_map( 'esc_sql', $skus ) ) . '")';
+			$args['where'] .= ' AND wc_product_meta_lookup.sku IN (\'' . implode( '\',\'', array_map( 'esc_sql', $skus ) ) . '\')';
 		}
 
 		if ( $wp_query->get( 'slug' ) ) {
@@ -375,10 +375,10 @@ class ProductQuery {
 
 		if ( $wp_query->get( 'stock_status' ) ) {
 			$args['join']   = $this->append_product_sorting_table_join( $args['join'] );
-			$args['where'] .= ' AND wc_product_meta_lookup.stock_status IN ("' . implode( '","', array_map( 'esc_sql', $wp_query->get( 'stock_status' ) ) ) . '")';
+			$args['where'] .= ' AND wc_product_meta_lookup.stock_status IN (\'' . implode( '\',\'', array_map( 'esc_sql', $wp_query->get( 'stock_status' ) ) ) . '\')';
 		} elseif ( 'yes' === get_option( 'woocommerce_hide_out_of_stock_items' ) ) {
 			$args['join']   = $this->append_product_sorting_table_join( $args['join'] );
-			$args['where'] .= ' AND wc_product_meta_lookup.stock_status NOT IN ("outofstock")';
+			$args['where'] .= ' AND wc_product_meta_lookup.stock_status NOT IN (\'outofstock\')';
 		}
 
 		if ( $wp_query->get( 'min_price' ) || $wp_query->get( 'max_price' ) ) {
diff --git a/plugins/woocommerce/src/StoreApi/Utilities/ProductQueryFilters.php b/plugins/woocommerce/src/StoreApi/Utilities/ProductQueryFilters.php
index 6d136d65e8d..9afe4db151b 100644
--- a/plugins/woocommerce/src/StoreApi/Utilities/ProductQueryFilters.php
+++ b/plugins/woocommerce/src/StoreApi/Utilities/ProductQueryFilters.php
@@ -153,8 +153,9 @@ class ProductQueryFilters {
 			},
 			$attributes
 		);
-		$attributes_to_count_sql = 'AND term_taxonomy.taxonomy IN ("' . implode( '","', $attributes_to_count ) . '")';
-		$attribute_count_sql     = "
+		$attributes_to_count_sql = 'AND term_taxonomy.taxonomy IN (\'' . implode( '\',\'', $attributes_to_count ) . '\')';
+
+		$attribute_count_sql = "
 			SELECT COUNT( DISTINCT posts.ID ) as term_count, terms.term_id as term_count_id
 			FROM {$wpdb->posts} AS posts
 			INNER JOIN {$wpdb->term_relationships} AS term_relationships ON posts.ID = term_relationships.object_id