diff --git a/plugins/woocommerce/changelog/51102-fix-settings-js-save-activation b/plugins/woocommerce/changelog/51102-fix-settings-js-save-activation
new file mode 100644
index 00000000000..c19d8648fb1
--- /dev/null
+++ b/plugins/woocommerce/changelog/51102-fix-settings-js-save-activation
@@ -0,0 +1,4 @@
+Significance: patch
+Type: fix
+
+Fix Settings Save button when WP List Tables are present
\ No newline at end of file
diff --git a/plugins/woocommerce/client/legacy/js/admin/settings.js b/plugins/woocommerce/client/legacy/js/admin/settings.js
index afa04cc564a..bc7f4c8b725 100644
--- a/plugins/woocommerce/client/legacy/js/admin/settings.js
+++ b/plugins/woocommerce/client/legacy/js/admin/settings.js
@@ -98,9 +98,10 @@
 				event
 			) {
 				// Toggling WP List Table checkboxes should not trigger navigation warnings.
+				// Theses checkboxes only select/unselect rows, they don't change the form.
 				if (
 					$check_column.length &&
-					$check_column.has( event.target )
+					$check_column.has( event.target ).length
 				) {
 					return;
 				}