diff --git a/plugins/woocommerce/changelog/44808-dev-fix-fatal-interactivity b/plugins/woocommerce/changelog/44808-dev-fix-fatal-interactivity
new file mode 100644
index 00000000000..6dc89f50aa5
--- /dev/null
+++ b/plugins/woocommerce/changelog/44808-dev-fix-fatal-interactivity
@@ -0,0 +1,4 @@
+Significance: patch
+Type: fix
+
+Fix a possible fatal exception setting a duplicate asset registry key `needsRefreshForInteractivityAPI`
\ No newline at end of file
diff --git a/plugins/woocommerce/src/Blocks/BlockTypes/ClassicTemplate.php b/plugins/woocommerce/src/Blocks/BlockTypes/ClassicTemplate.php
index c23a4366393..cace93045de 100644
--- a/plugins/woocommerce/src/Blocks/BlockTypes/ClassicTemplate.php
+++ b/plugins/woocommerce/src/Blocks/BlockTypes/ClassicTemplate.php
@@ -49,7 +49,7 @@ class ClassicTemplate extends AbstractDynamicBlock {
 
 		// Indicate to interactivity powered components that this block is on the page,
 		// and needs refresh to update data.
-		$this->asset_data_registry->add( 'needsRefreshForInteractivityAPI', true );
+		$this->asset_data_registry->add( 'needsRefreshForInteractivityAPI', true, true );
 	}
 
 	/**
diff --git a/plugins/woocommerce/src/Blocks/BlockTypes/ProductQuery.php b/plugins/woocommerce/src/Blocks/BlockTypes/ProductQuery.php
index 71ecaec1c52..351dc22f439 100644
--- a/plugins/woocommerce/src/Blocks/BlockTypes/ProductQuery.php
+++ b/plugins/woocommerce/src/Blocks/BlockTypes/ProductQuery.php
@@ -180,6 +180,7 @@ class ProductQuery extends AbstractBlock {
 			// and needs refresh to update data.
 			$this->asset_data_registry->add(
 				'needsRefreshForInteractivityAPI',
+				true,
 				true
 			);
 			// Set this so that our product filters can detect if it's a PHP template.