diff --git a/plugins/woocommerce/changelog/49632-fix-cys-6.6-test b/plugins/woocommerce/changelog/49632-fix-cys-6.6-test
new file mode 100644
index 00000000000..421b9fd198a
--- /dev/null
+++ b/plugins/woocommerce/changelog/49632-fix-cys-6.6-test
@@ -0,0 +1,4 @@
+Significance: patch
+Type: tweak
+Comment: Fixes `plugins/woocommerce/tests/e2e-pw/tests/customize-store/assembler/color-picker.spec.js`E2E tests when run on WordPress 6.6.
+
diff --git a/plugins/woocommerce/tests/e2e-pw/tests/customize-store/assembler/color-picker.spec.js b/plugins/woocommerce/tests/e2e-pw/tests/customize-store/assembler/color-picker.spec.js
index 06e5f941e39..6a5a91e646b 100644
--- a/plugins/woocommerce/tests/e2e-pw/tests/customize-store/assembler/color-picker.spec.js
+++ b/plugins/woocommerce/tests/e2e-pw/tests/customize-store/assembler/color-picker.spec.js
@@ -4,6 +4,7 @@ const { CustomizeStorePage } = require( '../customize-store.page' );
 const { encodeCredentials } = require( '../../../utils/plugin-utils' );
 
 const { activateTheme, DEFAULT_THEME } = require( '../../../utils/themes' );
+const { getInstalledWordPressVersion } = require( '../../../utils/wordpress' );
 const { setOption } = require( '../../../utils/options' );
 
 const test = base.extend( {
@@ -434,17 +435,22 @@ test.describe( 'Assembler -> Color Pickers', { tag: '@gutenberg' }, () => {
 				response.status() === 200
 		);
 
-		const waitResponseTemplate = page.waitForResponse(
-			( response ) =>
-				response.url().includes(
-					// When CYS will support all block themes, this URL will change.
-					'wp-json/wp/v2/templates/twentytwentyfour//home'
-				) && response.status() === 200
-		);
+		const wordPressVersion = await getInstalledWordPressVersion();
 
 		await saveButton.click();
 
-		await Promise.all( [ waitResponseGlobalStyles, waitResponseTemplate ] );
+		await Promise.all( [
+			waitResponseGlobalStyles,
+			wordPressVersion < 6.6
+				? page.waitForResponse(
+						( response ) =>
+							response.url().includes(
+								// When CYS will support all block themes, this URL will change.
+								'wp-json/wp/v2/templates/twentytwentyfour//home'
+							) && response.status() === 200
+				  )
+				: Promise.resolve(),
+		] );
 
 		await page.goto( baseURL );
 
@@ -510,6 +516,8 @@ test.describe( 'Assembler -> Color Pickers', { tag: '@gutenberg' }, () => {
 		baseURL,
 	}, testInfo ) => {
 		testInfo.snapshotSuffix = '';
+		const wordPressVersion = await getInstalledWordPressVersion();
+
 		const assembler = await assemblerPageObject.getAssembler();
 		const colorPicker = assembler.getByText( 'Create your own' );
 
@@ -585,7 +593,7 @@ test.describe( 'Assembler -> Color Pickers', { tag: '@gutenberg' }, () => {
 				.click();
 
 			// eslint-disable-next-line playwright/no-conditional-in-test
-			if ( gutenbergPlugin ) {
+			if ( gutenbergPlugin || wordPressVersion >= 6.6 ) {
 				for ( const feature of mapTypeFeaturesGutenberg[ type ] ) {
 					const container = assembler.locator(
 						'.block-editor-panel-color-gradient-settings__dropdown-content'
diff --git a/plugins/woocommerce/tests/e2e-pw/utils/wordpress.js b/plugins/woocommerce/tests/e2e-pw/utils/wordpress.js
index 9bc27a5078b..c36a21cd258 100644
--- a/plugins/woocommerce/tests/e2e-pw/utils/wordpress.js
+++ b/plugins/woocommerce/tests/e2e-pw/utils/wordpress.js
@@ -1,3 +1,6 @@
+const { promisify } = require( 'util' );
+const execAsync = promisify( require( 'child_process' ).exec );
+
 const getVersionWPLatestMinusOne = async ( { core, github } ) => {
 	const URL_WP_STABLE_VERSION_CHECK =
 		'https://api.wordpress.org/core/stable-check/1.0/';
@@ -21,4 +24,18 @@ const getVersionWPLatestMinusOne = async ( { core, github } ) => {
 	core.setOutput( 'version', latestMinus1 );
 };
 
-module.exports = { getVersionWPLatestMinusOne };
+const getInstalledWordPressVersion = async () => {
+	try {
+		const { stdout } = await execAsync(
+			`pnpm exec wp-env run tests-cli -- wp core version`
+		);
+
+		return Number.parseFloat( stdout.trim() );
+	} catch ( error ) {
+		throw new Error(
+			`Error getting WordPress version: ${ error.message }`
+		);
+	}
+};
+
+module.exports = { getVersionWPLatestMinusOne, getInstalledWordPressVersion };