diff --git a/assets/css/admin.scss b/assets/css/admin.scss
index 67ae21ee00f..b78e3429fa0 100644
--- a/assets/css/admin.scss
+++ b/assets/css/admin.scss
@@ -637,7 +637,7 @@ mark.amount {
 	}
 }
 
-.branch-5-3 {
+.wc-wp-version-gte-53 {
 
 	.woocommerce-help-tip {
 		font-size: 1.2em;
@@ -2167,7 +2167,7 @@ ul.wc_coupon_list_block {
 	}
 }
 
-.branch-5-3 {
+.wc-wp-version-gte-53 {
 
 	.widefat {
 
@@ -4123,7 +4123,7 @@ img.help_tip {
 	}
 }
 
-.branch-5-3 {
+.wc-wp-version-gte-53 {
 
 	.woocommerce {
 
@@ -6694,7 +6694,7 @@ table.bar_chart {
 	min-width: 400px !important;
 }
 
-.branch-5-3 {
+.wc-wp-version-gte-53 {
 
 	.select2-results {
 
@@ -6831,7 +6831,7 @@ table.bar_chart {
 
 	@each $name, $color in $wp_admin_colors {
 
-		&-#{$name}.branch-5-3 {
+		&-#{$name}.wc-wp-version-gte-53 {
 
 			.select2-dropdown {
 				border-color: $color;
diff --git a/assets/css/wc-setup.scss b/assets/css/wc-setup.scss
index d6d26e38f32..ccb0f2691d1 100644
--- a/assets/css/wc-setup.scss
+++ b/assets/css/wc-setup.scss
@@ -1185,7 +1185,7 @@ h3.jetpack-reasons {
 }
 
 .branch-5-2,
-.branch-5-3 {
+.wc-wp-version-gte-53 {
 
 	.location-input {
 		margin: 0;
@@ -1415,7 +1415,7 @@ p.jetpack-terms {
 }
 
 .branch-5-2,
-.branch-5-3 {
+.wc-wp-version-gte-53 {
 
 	.wc-wizard-service-setting-stripe_create_account,
 	.wc-wizard-service-setting-ppec_paypal_reroute_requests {
diff --git a/includes/admin/class-wc-admin.php b/includes/admin/class-wc-admin.php
index 23d27e5bd73..6932f817ca5 100644
--- a/includes/admin/class-wc-admin.php
+++ b/includes/admin/class-wc-admin.php
@@ -33,6 +33,9 @@ class WC_Admin {
 
 		// Disable WXR export of schedule action posts.
 		add_filter( 'action_scheduler_post_type_args', array( $this, 'disable_webhook_post_export' ) );
+
+		// Add body class for WP 5.3+ compatibility.
+		add_filter( 'admin_body_class', array( $this, 'include_admin_body_class' ) );
 	}
 
 	/**
@@ -306,6 +309,30 @@ class WC_Admin {
 		$args['can_export'] = false;
 		return $args;
 	}
+
+	/**
+	 * Include admin classes.
+	 *
+	 * @since 4.2.0
+	 * @param string $classes Body classes string.
+	 * @return string
+	 */
+	public function include_admin_body_class( $classes ) {
+		if ( false !== strpos( $classes, 'wc-wp-version-gte-53' ) ) {
+			return $classes;
+		}
+
+		$raw_version   = get_bloginfo( 'version' );
+		$version_parts = explode( '-', $raw_version );
+		$version       = count( $version_parts ) > 1 ? $version_parts[0] : $raw_version;
+
+		// Add WP 5.3+ compatibility class.
+		if ( $raw_version && version_compare( $version, '5.3', '>=' ) ) {
+			$classes .= ' wc-wp-version-gte-53';
+		}
+
+		return $classes;
+	}
 }
 
 return new WC_Admin();